The author studied the effect of ethionine upon the absorption epithelium of ileum with particular attention to the endoplasmic reticulum.
Five tenth per cent of DL-ethionine was added to the diet of the experimental group rats and they were sacrificed after 1,2, 3, and 4 weeks, respectively. The ileum were observed by the electron microscope.
The results obtained were summarized as follow
The changes were detachment of membrane bound ribosome, dilatation of endoplasmic reticulum, decrease of polysome with reciprocal increase of monosome, and dilatation of Golgi complex. These changes were occurred at 2nd to 3 rd week from start of ethionine feeding and more severe at fouth week.
These observation suggested that ethionine induced degenerative changes of the organelles.
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